TB-500 is a rapid muscle and injury repair peptide and a first-in-class natural peptide present in virtually all human and animal cells. It made up of 43 amino acids and is a major cellular constituent in many tissues throughout the human body.
It interacts with actin which is a major constituent of cells and the extra-cellular matrix and plays a role in the interactions between cells and their support systems.
It shows a remarkably diverse range of effects when present in the fluid surrounding animal tissue cells which suggests that it has a general role in tissue regeneration.
Work with cell cultures and experiments with animals has shown that administration of thymosin β4 can promote migration of cells, the formation of blood vessels, maturation of stem cells, the survival of various cell types, and the lowering of the production of pro-inflammatory cytokines.
TB-500 promotes blood vessel cell and skin cell regeneration and migration, resulting in more rapid and effective wound repair as well as faster recovery from injury.
This has lead to research about a variety of possible therapeutic applications, some of which have now been extended to animal models and human clinical trials.
The peptide has been tested in multicenter trials in the United States and Europe in patients with bedsores, ulcers caused by venostasis, and Epidermolysis bullosa simplex, and was found to accelerate bedsore and stasis ulcer repair.
It was found to promote wound healing in both full-thickness skin wounds and heptanol debrided corneas while decreasing both PMN infiltration and inflammatory cytokine and chemokine mRNA levels.
Furthermore, this amazing peptide has been shown to increase the production of matrix metalloproteinases that may degrade the basement membrane during angiogenesis allowing for more effective blood vessel formation.
On the whole, TB-500 is considered the highest quality and most effective peptide in the family for bone, muscle, and injury repair as well as healing ability in healthy adult subjects.
TB-500 is sold in vials containing 2MG of lyophilised powder which can be reconstituted by adding a convenient amount of sterile or bacteriostatic water.
TB-500 is sold in vials containing 5MG of lyophilised powder which should be stored under refrigeration. (It is acceptable however for them to be mailed unrefrigerated). The contents can be reconstituted by adding a convenient amount of sterile or bacteriostatic water.
5mg of powder
2.5ml of bacteriostatic water
equals 2,000 mcg/ml
At time of dosing, an insulin syringe is used to draw and then inject the desired amount. In the above example a 2,000 mcg (or 2mg) dose would require 1 mL, or “100 IU” as marked on an insulin syringe.
The most common dosing protocol is to take 2.0 or 2.5 mg of TB-500 either once or up to twice per week for four to six weeks, and then reduce to a lower dosing rate thereafter.
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